By Jeffrey M. Drazen (auth.), Zeliha Yazici, Giancarlo C. Folco, Jeffrey M. Drazen, Santosh Nigam, Takao Shimizu (eds.)
This quantity, the complaints of the twelfth overseas convention on Advances in Prostaglandin, Leukotriene and different Bioactive Lipid examine: uncomplicated technological know-how and scientific purposes, held August 25-29, 2002, in Istanbul, Turkey, discusses advances in bioactive lipid examine with designated consciousness to melanoma, cardiovascular ailments, gastrointestinal ailments and breathing illnesses. particular themes lined comprise the function of leukotrienes and lipoxins in irritation, the cytochrome P450 pathway, the genetics and genomics of bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors.
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Additional resources for Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research: Basic Science and Clinical Applications
The results of this study showed that IL-4 induced expression of l5-LO in human monocytes is accompanied by a significant inhibition of LTB4 production upon challenge with either the Ca++-ionophore A23l87 or a physiologically relevant stimulus such as opsonized zymosan. The potential for IL-4 to significantly change the profile of arachidonic acid metabolites from the production of leukotrienes to thatof l5(S)-HETE raises important questions on the biological relevance of such an effect. Recently we have shown that l5(S)-HETE is present in high concentration in induced sputum obtained from chronic bronchitis patients, and that its concentration inversely correlate both with the percentage of neutrophils recovered and the concentration of LTB4 in induced sputum .
To LB, Haylock DN, Simmons PJ, Juttner CA. The biology and clinical uses of blood stem cells. Blood 1997; 89:2233-2258. Denzlinger C. Biology and pathophysiology of leukotrienes. Crit Rev Oncol Hematol 1996; 23:167-223. 28 3. 4. 5. 6. 7. TRAFFICKING OF HEMATOPOIETIC PROGENITOR CELLS Mahle R, Bautz F, Rafii S, et al. Regulation of transendothelial migration of hematopoietic progenitor cells. Ann NY Acad Sci 1999; 872:176-186. Stenke L, Lauren L, Reizenstein P, Lindgren lA. Leukotriene production by fresh human bone marrow cells: evidence of altered lipoxygenase activity in chronic myelocytic leukemia.
An interesting feature of these experiments was that the activation of the RBL-2H3 cells was critical for the formation of LT~ adducts with DNA present in the nucleus of the RBL-2H3 cells. The elevation of intracellular calcium therefore appeared to be an important step, driving the access of LT~ to target DNA. The reason for a requirement for cell activation in order to observe LT~ adduct formation with DNA is not at present understood, but the requirement for exogenous LT~ stems from the fact that RBL-2H3 cells produce very low levels of endogenous LT~ when stimulated with the calcium ionophore.